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  • 22 décembre 2023

    Molecular determinants of ligand efficacy and potency in GPCR signaling.

    Heydenreich FM, Marti-Solano M, Sandhu M, Kobilka BK, Bouvier M, Babu MM
    Science 2023-12-22 ;382( 6677 ):eadh1859

  • 16 décembre 2023

    The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma.

    Houles T, Boucher J, Lavoie G, MacLeod G, Lin S, Angers S, Roux PP
    Cell Death Discov 2023-12-16 ;9( 1 ):459

  • 15 décembre 2023

    DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML.

    Spinella JF, Chagraoui J, Moison C, Lavallée VP, Boivin I, Gracias D, Lavallée S, Carpentier GR, Beliveau F, Hébert J, Sauvageau G
    Leukemia 2023-12-15 ;

  • 14 décembre 2023

    The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

    Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF
    Cell Rep 2023-12-14 ;42( 12 ):113604

  • 14 décembre 2023

    Detection of metabolic adaptation in a triple-negative breast cancer animal model with [18F]choline-PET imaging as a surrogate for drug resistance.

    Kohan AA, Lupien M, Cescon D, Deblois G, Ventura M, Metser U, Veit-Haibach P
    Eur J Nucl Med Mol Imaging 2023-12-14 ;

  • 11 décembre 2023

    Silicone Particles in Capsules Around Breast Implants: An Investigation Into Currently Available Implants in North America.

    Danino MA, Dziubek M, Dalfen J, Bonapace-Potvin M, Gaboury L, Giot JP, Laurent R
    Aesthet Surg J 2023-12-11 ;

  • 1er décembre 2023

    Medicinal chemistry and NMR driven discovery of novel UDP-glucuronsyltransferase 1A inhibitors that overcome therapeutic resistance in cells.

    Osborne MJ, Sulekha A, Culjkovic-Kraljacic B, Gasiorek J, Ruediger E, Jolicouer E, Marinier A, Assouline S, Borden K
    J Mol Biol 2023-12-01 ;168378

  • 30 novembre 2023

    How carvedilol does not activate β2-adrenoceptors.

    Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M
    Nat Commun 2023-11-30 ;14( 1 ):7866

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