281 résultats
Targeting of human cancer stem cells predicts efficacy and toxicity of FDA-approved oncology drugs.
Vojnits K, Feng Z, Johnson P, Pfammatter S, Thibault P, Bhatia M
Cancer Lett
2024-07-08
;217108.
Comprehensive proteomic analysis of HCoV-OC43 virions and virus-modulated extracellular vesicles.
Joharinia N, Bonneil E, Grandvaux N, Thibault P, Lippé R
J Virol
2024-07-02
;e0085024.
Immunotherapeutic targeting of surfaceome heterogeneity in AML.
Bordeleau ME, Audemard E, Métois A, Theret L, Lisi V, Farah A, Spinella JF, Chagraoui J, Moujaber O, Aubert L, Khakipoor B, Mallinger L, Boivin I, Mayotte N, Hajmirza A, Bonneil E, Béliveau F, Pfammatter S, Feghaly A, Boucher G, Gendron P, Thibault P, Barabé F, Lemieux S, Richard-Carpentier G, Hébert J, Lavallée VP, Roux PP, Sauvageau G
Cell Rep
2024-06-04
;43(
6
):114260.
K29-linked free polyubiquitin chains affect ribosome biogenesis and direct ribosomal proteins to the intranuclear quality control compartment.
Garadi Suresh H, Bonneil E, Albert B, Dominique C, Costanzo M, Pons C, Masinas MPD, Shuteriqi E, Shore D, Henras AK, Thibault P, Boone C, Andrews BJ
Mol Cell
2024-06-01
;.
Immunogenicity of Non-Mutated Ovarian Cancer-Specific Antigens.
Hesnard L, Thériault C, Cahuzac M, Durette C, Vincent K, Hardy MP, Lanoix J, Lavallée GO, Humeau J, Thibault P, Perreault C
Curr Oncol
2024-05-30
;31(
6
):3099-3121.
Transposable elements regulate thymus development and function.
Larouche JD, Laumont CM, Trofimov A, Vincent K, Hesnard L, Brochu S, Côté C, Humeau JF, Bonneil E, Lanoix J, Durette C, Gendron P, Laverdure JP, Richie ER, Lemieux S, Thibault P, Perreault C
Elife
2024-04-18
;12:.
Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia.
Noronha N, Durette C, Cahuzac M, E Silva B, Courtois J, Humeau J, Sauvat A, Hardy MP, Vincent K, Laverdure JP, Lanoix J, Baron F, Thibault P, Perreault C, Ehx G
Leukemia
2024-04-16
;.
SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia.
Moison C, Gracias D, Schmitt J, Girard S, Spinella JF, Fortier S, Boivin I, Mendoza-Sanchez R, Thavonekham B, MacRae T, Mayotte N, Bonneil E, Wittman M, Carmichael J, Ruel R, Thibault P, Hébert J, Marinier A, Sauvageau G
Sci Adv
2024-03-22
;10(
12
):eadl4018.
O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis.
Masclef L, Ahmed O, Iannantuono N, Gagnon J, Gushul-Leclaire M, Boulay K, Estavoyer B, Echbicheb M, Poy M, Ali Boubacar K, Boubekeur A, Menggad S, Schcolnik-Cabrera A, Balsalobre A, Bonneil E, Thibault P, Hulea L, Tanaka Y, Antoine-Mallette F, Drouin J, Affar EB
bioRxiv
2024-03-01
;.
SUMO Modifies GβL and Mediates mTOR Signaling.
Park SLL, Ramírez-Jarquín UN, Shahani N, Rivera O, Sharma M, Joshi PS, Hansalia A, Dagar S, McManus FP, Thibault P, Subramaniam S
J Biol Chem
2024-02-21
;105778.
Involvement of extracellular vesicles in the proinflammatory response to clozapine: implications for clozapine-induced agranulocytosis.
Sernoskie SC, Bonneil E, Thibault P, Jee A, Uetrecht J
J Pharmacol Exp Ther
2024-01-23
;.
Targeted Mass Spectrometry Analyses of Somatic Mutations in Colorectal Cancer Specimens Using Differential Ion Mobility.
Wu Z, Bonneil E, Belford M, Boeser C, Dunyach JJ, Thibault P
J Proteome Res
2023-12-28
;.
Breast cancer immunopeptidomes contain numerous shared tumor antigens.
Kina E, Laverdure JP, Durette C, Lanoix J, Courcelles M, Zhao Q, Apavaloaei A, Larouche JD, Hardy MP, Vincent K, Gendron P, Hesnard L, Thériault C, Ruiz Cuevas MV, Ehx G, Thibault P, Perreault C
J Clin Invest
2023-10-31
;.
CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216.
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard E, Thibault P, Bonneil E, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith M, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm B, Cellot S
Blood Adv
2023-09-20
;.
Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption.
Kho I, Demina EP, Pan X, Londono I, Cairo CW, Sturiale L, Palmigiano A, Messina A, Garozzo D, Ung RV, Mac-Way F, Bonneil E, Thibault P, Lemaire M, Morales CR, Pshezhetsky AV
JCI Insight
2023-09-12
;.
BamQuery: a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens.
Cuevas MVR, Hardy MP, Larouche JD, Apavaloaei A, Kina E, Vincent K, Gendron P, Laverdure JP, Durette C, Thibault P, Lemieux S, Perreault C, Ehx G
Genome Biol
2023-08-15
;24(
1
):188.
A Rapid and Efficient Method for the Extraction of Histone Proteins.
Homsi C, Rajan RE, Minati R, St-Hilaire E, Bonneil E, Dufresne SF, Wurtele H, Verreault A, Thibault P
J Proteome Res
2023-08-04
;22(
8
):2765-2773.
Identification of PP2A-B55 targets uncovers regulation of emerin during nuclear envelope reassembly in Drosophila.
Emond-Fraser V, Larouche M, Kubiniok P, Bonneil E, Li J, Bourouh M, Frizzi L, Thibault P, Archambault V
Open Biol
2023-07-01
;13(
7
):230104.
Unlocking the potential of microfluidics in mass spectrometry-based immunopeptidomics for tumor antigen discovery.
Stutzmann C, Peng J, Wu Z, Savoie C, Sirois I, Thibault P, Wheeler AR, Caron E
Cell Rep Methods
2023-06-26
;3(
6
):100511.
K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ).
Suresh HG, Bonneil E, Albert B, Dominique C, Costanzo M, Pons C, David Masinas MP, Shuteriqi E, Shore D, Henras AK, Thibault P, Boone C, Andrews BJ
bioRxiv
2023-05-04
;.
OpenCustomDB: Integration of Unannotated Open Reading Frames and Genetic Variants to Generate More Comprehensive Customized Protein Databases.
Guilloy N, Brunet MA, Leblanc S, Jacques JF, Hardy MP, Ehx G, Lanoix J, Thibault P, Perreault C, Roucou X
J Proteome Res
2023-03-24
;.
Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire.
Millar DG, Yang SYC, Sayad A, Zhao Q, Nguyen LT, Warner K, Sangster AG, Nakatsugawa M, Murata K, Wang BX, Shaw P, Clarke B, Bernardini MQ, Pugh T, Thibault P, Hirano N, Perreault C, Ohashi PS
Cancer Immunol Immunother
2023-03-21
;.
SUMO Proteomics Analyses Identify Protein Inhibitor of Activated STAT-Mediated Regulatory Networks Involved in Cell Cycle and Cell Proliferation.
Li C, Boutet A, Pascariu CM, Nelson T, Courcelles M, Wu Z, Comtois-Marotte S, Emery G, Thibault P
J Proteome Res
2023-03-03
;22(
3
):812-825.
Histone H4K20 monomethylation enables recombinant nucleosome methylation by PRMT1 in vitro.
Li ASM, Homsi C, Bonneil E, Thibault P, Verreault A, Vedadi M
Biochim Biophys Acta Gene Regul Mech
2023-02-21
;1866(
2
):194922.
RNA helicase DDX3X modulates herpes simplex virus 1 nuclear egress.
Khadivjam B, Bonneil E, Thibault P, Lippé R
Commun Biol
2023-02-01
;6(
1
):134.
Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy.
Javary J, Goupil E, Soulez M, Kanshin E, Bouchard A, Seternes OM, Thibault P, Labbé J, Meloche S
J Cell Physiol
2022-12-28
;.
Proteogenomics and Differential Ion Mobility Enable the Exploration of the Mutational Landscape in Colon Cancer Cells.
Wu Z, Bonneil E, Belford M, Boeser C, Ruiz Cuevas MV, Lemieux S, Dunyach JJ, Thibault P
Anal Chem
2022-09-06
;94(
35
):12086-12094.
Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers.
Apavaloaei A, Hesnard L, Hardy MP, Benabdallah B, Ehx G, Thériault C, Laverdure JP, Durette C, Lanoix J, Courcelles M, Noronha N, Chauhan KD, Lemieux S, Beauséjour C, Bhatia M, Thibault P, Perreault C
Cell Rep
2022-08-16
;40(
7
):111241.
Immunopeptidomics: Reading the Immune Signal That Defines Self From Nonself.
Thibault P, Perreault C
Mol Cell Proteomics
2022-05-11
;21(
6
):100234.
Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability.
Cleyle J, Hardy MP, Minati R, Courcelles M, Durette C, Lanoix J, Laverdure JP, Vincent K, Perreault C, Thibault P
Mol Cell Proteomics
2022-05-01
;21(
5
):100228.
Head-to-tail cyclization of side chain-protected linear peptides to recapitulate genetically-encoded cyclized peptides.
Bouayad-Gervais S, St-Cyr DJ, Courcelles M, Bonneil E, Gohard FH, Thibault P, Earnshaw WC, Tyers M
Pept Sci (Hoboken)
2022-05-01
;114(
3
):e24254.
The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.
Tollis S, Singh J, Palou R, Thattikota Y, Ghazal G, Coulombe-Huntington J, Tang X, Moore S, Blake D, Bonneil E, Royer CA, Thibault P, Tyers M
PLoS Biol
2022-03-01
;20(
3
):e3001548.
Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes.
Beillevaire D, Migneault F, Turgeon J, Gingras D, Rimbaud AK, Marcoux G, Spino C, Thibodeau N, Bonneil E, Thibault P, Boilard E, Dieudé M, Hébert MJ
Cell Death Dis
2022-02-11
;13(
2
):145.
MhcVizPipe: A Quality Control Software for Rapid Assessment of Small- to Large-Scale Immunopeptidome Datasets.
Kovalchik KA, Ma Q, Wessling L, Saab F, D Duquette J, Kubiniok P, Hamelin DJ, Faridi P, Li C, Purcell AW, Jang A, Paramithiotis E, Tognetti M, Reiter L, Bruderer R, Lanoix J, Bonneil E, Courcelles M, Thibault P, Caron E, Sirois I
Mol Cell Proteomics
2021-11-17
;21(
1
):100178.
CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation.
Daouda T, Dumont-Lagacé M, Feghaly A, Benslimane Y, Panes R, Courcelles M, Benhammadi M, Harrington L, Thibault P, Major F, Bengio Y, Gagnon E, Lemieux S, Perreault C
PLoS Comput Biol
2021-10-22
;17(
10
):e1009482.
Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission.
Pará C, Bose P, Bruno L, Freemantle E, Taherzadeh M, Pan X, Han C, McPherson PS, Lacaille JC, Bonneil E, Thibault P, O'Leary C, Bigger B, Morales CR, Di Cristo G, Pshezhetsky AV
JCI Insight
2021-08-09
;6(
15
):.
Integration of Segmented Ion Fractionation and Differential Ion Mobility on a Q-Exactive Hybrid Quadrupole Orbitrap Mass Spectrometer.
Pfammatter S, Wu Z, Bonneil E, Bailey DJ, Prasad S, Belford M, Rochon J, Picard P, Lacoursière J, Dunyach JJ, Thibault P
Anal Chem
2021-07-20
;93(
28
):9817-9825.
A bacterium-derived, cancer-associated immunopeptidome.
Perreault C, Thibault P, Kroemer G
Oncoimmunology
2021-05-03
;10(
1
):1918373.
Crosstalk Between SUMO and Ubiquitin-Like Proteins: Implication for Antiviral Defense.
Chelbi-Alix MK, Thibault P
Front Cell Dev Biol
2021-04-21
;9:671067.
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.
Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Thériault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, Hébert J, Sauvageau G, Lemieux S, Thibault P, Perreault C
Immunity
2021-04-13
;54(
4
):737-752.e10.
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.
MacNeil DE, Lambert-Lanteigne P, Qin J, McManus FP, Bonneil E, Thibault P, Autexier C
Mol Cell Biol
2021-03-24
;41(
4
):.
Most non-canonical proteins uniquely populate the proteome or immunopeptidome.
Ruiz Cuevas MV, Hardy MP, Hollý J, Bonneil E, Durette C, Courcelles M, Lanoix J, Côté C, Staudt LM, Lemieux S, Thibault P, Perreault C, Yewdell JW
Cell Rep
2021-03-09
;34(
10
):108815.
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.
Benslimane Y, Sánchez-Osuna M, Coulombe-Huntington J, Bertomeu T, Henry D, Huard C, Bonneil E, Thibault P, Tyers M, Harrington L
Aging Cell
2021-03-04
;e13331.
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.
Chagraoui J, Girard S, Spinella JF, Simon L, Bonneil E, Mayotte N, MacRae T, Coulombe-Huntington J, Bertomeu T, Moison C, Tomellini E, Thibault P, Tyers M, Marinier A, Sauvageau G
Cell Stem Cell
2021-01-07
;28(
1
):48-62.e6.
A Roadmap Toward the Definition of Actionable Tumor-Specific Antigens.
Minati R, Perreault C, Thibault P
Front Immunol
2020-12-03
;11:583287.
H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone.
Khazaei S, De Jay N, Deshmukh S, Hendrikse LD, Jawhar W, Chen CCL, Mikael LG, Faury D, Marchione DM, Lanoix J, Bonneil E, Ishii T, Jain SU, Rossokhata K, Sihota TS, Eveleigh R, Lisi V, Harutyunyan AS, Jung S, Karamchandani J, Dickson BC, Turcotte R, Wunder JS, Thibault P, Lewis PW, Garcia BA, Mack SC, Taylor MD, Garzia L, Kleinman CL, Jabado N
Cancer Discov
2020-12-01
;10(
12
):1968-1987.
Proteomics of Herpes Simplex Virus Type 1 Nuclear Capsids.
El Bilali N, Khadivjam B, Bonneil E, Thibault P, Lippé R
J Virol
2020-11-25
;95(
4
):e01842-19.
Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.
Garrido D, Bourouh M, Bonneil E, Thibault P, Swan A, Archambault V
PLoS Genet
2020-11-02
;16(
11
):e1009184.
Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age.
Grenier-Pleau I, Tyryshkin K, Le TD, Rudan J, Bonneil E, Thibault P, Zeng K, Lässer C, Mallinson D, Lamprou D, Hui J, Postovit LM, Chan EYW, Abraham SA
Aging Cell
2020-10-07
;e13245.
The Origin and Immune Recognition of Tumor-Specific Antigens.
Apavaloaei A, Hardy MP, Thibault P, Perreault C
Cancers (Basel)
2020-09-12
;12(
9
):.