145 résultats
eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production.
Mars JC, Culjkovic-Kraljacic B, Borden K
Nucleus
2024-06-16
;15(
1
):2360196.
Medicinal chemistry and NMR driven discovery of novel UDP-glucuronsyltransferase 1A inhibitors that overcome therapeutic resistance in cells.
Osborne MJ, Sulekha A, Culjkovic-Kraljacic B, Gasiorek J, Ruediger E, Jolicouer E, Marinier A, Assouline S, Borden K
J Mol Biol
2023-12-01
;168378.
The eukaryotic translation initiation factor eIF4E unexpectedly acts in splicing thereby coupling mRNA processing with translation: eIF4E induces widescale splicing reprogramming providing system-wide connectivity between splicing, nuclear mRNA export and translation.
Borden K
Bioessays
2023-11-05
;e2300145.
XPO1 enables adaptive regulation of mRNA export required for genotoxic stress tolerance in cancer cells.
Marullo R, Rutherford SC, Revuelta MV, Zamponi N, Culijkovic B, Kotlov N, Di Siervi N, Lara-Garcia J, Allan JN, Ruan J, Furman RR, Chen Z, Shore TB, Phillips AA, Mayer S, Hsu J, van Besien K, Leonard JP, Borden K, Inghirami G, Martin P, Cerchietti L
Cancer Res
2023-10-06
;.
Molecular targeting of the UDP-glucuronosyltransferase enzymes in high-eukaryotic translation initiation factor 4E refractory/relapsed acute myeloid leukemia patients: a randomized phase II trial of vismodegib, ribavirin with or without decitabine.
Assouline S, Gasiorek J, Bergeron J, Lambert C, Culjkovic-Kraljacic B, Cocolakis E, Zakaria C, Szlachtycz D, Yee K, Borden K
Haematologica
2023-03-23
;.
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.
Ghram M, Morris G, Culjkovic-Kraljacic B, Mars JC, Gendron P, Skrabanek L, Revuelta MV, Cerchietti L, Guzman ML, Borden K
EMBO J
2023-02-27
;e110496.
1H, 13C, 15N Backbone and sidechain chemical shift assignments of the C-terminal domain of human UDP-glucuronosyltransferase 2B17 (UGT2B17-C).
Sulekha A, Osborne MJ, Gasiorek J, Borden K
Biomol NMR Assign
2023-02-09
;.
Cancer cells hijack RNA processing to rewrite the message.
Borden K
Biochem Soc Trans
2022-10-31
;50(
5
):1447-1456.
Unorthodox PCNA Binding by Chromatin Assembly Factor 1.
Gopinathan Nair A, Rabas N, Lejon S, Homiski C, Osborne MJ, Cyr N, Sverzhinsky A, Melendy T, Pascal JM, Laue ED, Borden K, Omichinski JG, Verreault A
Int J Mol Sci
2022-09-21
;23(
19
):.
The search for genetic dark matter and lessons learned from the journey.
Borden K
Biochem Cell Biol
2022-08-01
;100(
4
):276-281.
Identification and Characterization of the Interaction Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E.
Osborne MJ, Volpon L, Memarpoor-Yazdi M, Pillay S, Thambipillai A, Czarnota S, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Cowling VH, Borden K
J Mol Biol
2022-01-10
;434(
5
):167451.
Subcellular Fractionation Suitable for Studies of RNA and Protein Trafficking.
Culjkovic-Kraljacic B, Borden K
Methods Mol Biol
2022-01-01
;2502:91-104.
The Cap-Binding Complex CBC and the Eukaryotic Translation Factor eIF4E: Co-Conspirators in Cap-Dependent RNA Maturation and Translation.
Mars JC, Ghram M, Culjkovic-Kraljacic B, Borden K
Cancers (Basel)
2021-12-08
;13(
24
):.
1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C).
Osborne MJ, Rahardjo AK, Volpon L, Borden K
Biomol NMR Assign
2021-10-01
;15(
2
):323-328.
To cap it all off, again: dynamic capping and recapping of coding and non-coding RNAs to control transcript fate and biological activity.
Borden K, Culjkovic-Kraljacic B, Cowling VH
Cell Cycle
2021-07-09
;20(
14
):1347-1360.
The Nuclear Pore Complex and mRNA Export in Cancer.
Borden K
Cancers (Basel)
2020-12-25
;13(
1
):.
The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts.
Culjkovic-Kraljacic B, Skrabanek L, Revuelta MV, Gasiorek J, Cowling VH, Cerchietti L, Borden K
Proc Natl Acad Sci U S A
2020-10-27
;117(
43
):26773-26783.
The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery.
Borden K, Volpon L
RNA Biol
2020-06-04
;1-13.
Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.
Coutinho de Oliveira L, Volpon L, Rahardjo AK, Osborne MJ, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Kwok B, Borden K
Proc. Natl. Acad. Sci. U.S.A.
2019-12-07
;116(
48
):24056-24065.
Nuclear eIF4E Stimulates 3’-End Cleavage of Target RNAs.
Davis MR, Delaleau M, Borden K
Cell Rep
2019-04-30
;27(
5
):1397-1408.e4.
Chemical shift assignment of the viral protein genome-linked (VPg) from potato virus Y.
Coutinho de Oliveira L, Volpon L, Osborne MJ, Borden K
Biomol NMR Assign
2019-04-01
;13(
1
):9-13.
GLI1-Inducible Glucuronidation Targets a Broad Spectrum of Drugs.
Zahreddine HA, Culjkovic-Kraljacic B, Gasiorek J, Duchaine J, Borden K
ACS Chem. Biol.
2019-03-15
;14(
3
):348-355.
CDK9 and mTOR: trading places.
Borden K
Blood
2019-03-14
;133(
11
):1167-1168.
Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.
Urtishak KA, Wang LS, Culjkovic-Kraljacic B, Davenport JW, Porazzi P, Vincent TL, Teachey DT, Tasian SK, Moore JS, Seif AE, Jin S, Barrett JS, Robinson BW, Chen IL, Harvey RC, Carroll MP, Carroll AJ, Heerema NA, Devidas M, Dreyer ZE, Hilden JM, Hunger SP, Willman CL, Borden K, Felix CA
Oncogene
2019-03-01
;38(
13
):2241-2262.
Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes.
Osborne MJ, Coutinho de Oliveira L, Volpon L, Zahreddine HA, Borden K
J. Mol. Biol.
2019-01-18
;431(
2
):258-272.
Biochemical and Structural Insights into the Eukaryotic Translation Initiation Factor eIF4E.
Volpon L, Osborne MJ, Borden K
Curr. Protein Pept. Sci.
2019-01-01
;20(
6
):525-535.
The Impact of Post-transcriptional Control: Better Living Through RNA Regulons.
Culjkovic-Kraljacic B, Borden K
Front Genet
2018-11-05
;9:512.
Backbone assignment of the apo-form of the human C-terminal domain of UDP-glucuronosyltransferase 1A (UGT1A).
Osborne MJ, Coutinho de Oliveira L, Volpon L, Borden K
Biomol NMR Assign
2018-10-01
;12(
2
):315-318.
BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.
Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, Brunsdon H, Berridge G, Picaud S, Fischer R, Lisle R, Knapp S, Filippakopoulos P, Knowles H, Steingrímsson E, Borden K, Patton EE, Goding CR
Proc. Natl. Acad. Sci. U.S.A.
2018-09-11
;115(
37
):E8668-E8677.
A TFEB nuclear export signal integrates amino acid supply and glucose availability.
Li L, Friedrichsen HJ, Andrews S, Picaud S, Volpon L, Ngeow K, Berridge G, Fischer R, Borden K, Filippakopoulos P, Goding CR
Nat Commun
2018-07-11
;9(
1
):2685.
The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity.
Zahreddine HA, Culjkovic-Kraljacic B, Emond A, Pettersson F, Midura R, Lauer M, Del Rincon S, Cali V, Assouline S, Miller WH, Hascall V, Borden K
Elife
2017-11-07
;6:.
A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.
Volpon L, Culjkovic-Kraljacic B, Sohn HS, Blanchet-Cohen A, Osborne MJ, Borden K
RNA
2017-06-01
;23(
6
):927-937.
The eukaryotic translation initiation factor eIF4E wears a “cap” for many occasions.
Borden K
Translation (Austin)
2016-08-10
;4(
2
):e1220899.
Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.
Volpon L, Culjkovic-Kraljacic B, Osborne MJ, Ramteke A, Sun Q, Niesman A, Chook YM, Borden K
Proc. Natl. Acad. Sci. U.S.A.
2016-05-10
;113(
19
):5263-8.
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.
Culjkovic-Kraljacic B, Fernando TM, Marullo R, Calvo-Vidal N, Verma A, Yang S, Tabbò F, Gaudiano M, Zahreddine H, Goldstein RL, Patel J, Taldone T, Chiosis G, Ladetto M, Ghione P, Machiorlatti R, Elemento O, Inghirami G, Melnick A, Borden K, Cerchietti L
Blood
2016-02-18
;127(
7
):858-68.
Multiple Export Mechanisms for mRNAs.
Delaleau M, Borden K
Cells
2015-08-28
;4(
3
):452-73.
Molecular Pathways: GLI1-Induced Drug Glucuronidation in Resistant Cancer Cells.
Zahreddine HA, Borden K
Clin. Cancer Res.
2015-05-15
;21(
10
):2207-10.
Sonic Hedgehog factor Gli1: As good as resistant.
Zahreddine HA, Culjkovic-Kraljacic B, Borden K
Mol Cell Oncol
2015-02-24
;2(
1
):e961827.
A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E.
Assouline S, Culjkovic-Kraljacic B, Bergeron J, Caplan S, Cocolakis E, Lambert C, Lau CJ, Zahreddine HA, Miller WH, Borden K
Haematologica
2015-01-01
;100(
1
):e7-9.
The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled.
Osborne MJ, Borden K
Immunol. Rev.
2015-01-01
;263(
1
):210-23.
When Will Resistance Be Futile?
Borden K
Cancer Res.
2014-12-15
;74(
24
):7175-7180.
MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden K, Gartenhaus RB
Nat Commun
2014-11-18
;5:5413.
Inducible drug modification: A new form of resistance.
Culjkovic-Kraljacic B, Zahreddine HA, Borden K
Cell Cycle
2014-08-15
;13(
16
):2485-6.
TIF-90 tips the balance in rRNA synthesis.
Borden K
Blood
2014-07-24
;124(
4
):467-8.
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.
Zahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden K
Nature
2014-07-03
;511(
7507
):90-3.
LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase.
Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden K, Rauscher FJ
Cancer Res.
2014-03-01
;74(
5
):1390-403.
The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia.
Hariri F, Arguello M, Volpon L, Culjkovic-Kraljacic B, Nielsen TH, Hiscott J, Mann KK, Borden K
Leukemia
2013-10-01
;27(
10
):2047-55.
Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma.
Clozel T, Yang S, Elstrom RL, Tam W, Martin P, Kormaksson M, Banerjee S, Vasanthakumar A, Culjkovic B, Scott DW, Wyman S, Leser M, Shaknovich R, Chadburn A, Tabbo F, Godley LA, Gascoyne RD, Borden K, Inghirami G, Leonard JP, Melnick A, Cerchietti L
Cancer Discov
2013-09-01
;3(
9
):1002-1019.
Aiding and abetting cancer: mRNA export and the nuclear pore.
Culjkovic-Kraljacic B, Borden K
Trends Cell Biol.
2013-07-01
;23(
7
):328-35.
RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.
Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden K, Meloche S, Roux PP
Oncogene
2013-06-13
;32(
24
):2917-26.