36 résultats
Detection of metabolic adaptation in a triple-negative breast cancer animal model with [18F]choline-PET imaging as a surrogate for drug resistance.
Kohan AA, Lupien M, Cescon D, Deblois G, Ventura M, Metser U, Veit-Haibach P
Eur J Nucl Med Mol Imaging
2023-12-14
;.
Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer.
Cameron S, Deblois G, Hawley JR, Qamra A, Zhou S, Tonekaboni SAM, Murison A, Van Vliet R, Liu J, Locasale JW, Lupien M
Oncogene
2023-04-05
;.
Profiling the Epigenetic Landscape of the Tumor Microenvironment Using Chromatin Immunoprecipitation Sequencing.
Fukano M, Alzial G, Lambert R, Deblois G
Methods Mol Biol
2023-01-01
;2614:313-348.
3D chromatin remodeling potentiates transcriptional programs driving cell invasion.
Lebeau B, Jangal M, Zhao T, Wong CK, Wong N, Cañedo EC, Hébert S, Aguilar-Mahecha A, Chabot C, Buchanan M, Catterall R, McCaffrey L, Deblois G, Kleinman C, Park M, Basik M, Witcher M
Proc Natl Acad Sci U S A
2022-09-06
;119(
36
):e2203452119.
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.
Wu Q, Nie DY, Ba-Alawi W, Ji Y, Zhang Z, Cruickshank J, Haight J, Ciamponi FE, Chen J, Duan S, Shen Y, Liu J, Marhon SA, Mehdipour P, Szewczyk MM, Dogan-Artun N, Chen W, Zhang LX, Deblois G, Prinos P, Massirer KB, Barsyte-Lovejoy D, Jin J, De Carvalho DD, Haibe-Kains B, Wang X, Cescon DW, Lupien M, Arrowsmith CH
Nat Chem Biol
2022-08-01
;18(
8
):821-830.
Metabolic Flexibility Is a Determinant of Breast Cancer Heterogeneity and Progression.
Fukano M, Park M, Deblois G
Cancers (Basel)
2021-09-19
;13(
18
):.
p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors.
Cañedo EC, Totten S, Ahn R, Savage P, MacNeil D, Hudson J, Autexier C, Deblois G, Park M, Witcher M, Ursini-Siegel J
JCI Insight
2021-02-22
;6(
4
):.
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Xu G, van Bruggen R, Gualtieri CO, Moradin N, Fois A, Vallerand D, De Sa Tavares Russo M, Bassenden A, Lu W, Tam M, Lesage S, Girouard H, Avizonis DZ, Deblois G, Prchal JT, Stevenson M, Berghuis A, Muir T, Rabinowitz J, Vidal SM, Fodil N, Gros P
Cell Rep
2020-09-22
;32(
12
):108170.
Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.
Deblois G, Tonekaboni SAM, Grillo G, Martinez C, Kao YI, Tai F, Ettayebi I, Fortier AM, Savage P, Fedor AN, Liu X, Guilhamon P, Lima-Fernandes E, Murison A, Kuasne H, Ba-Alawi W, Cescon DW, Arrowsmith CH, De Carvalho DD, Haibe-Kains B, Locasale JW, Park M, Lupien M
Cancer Discov
2020-09-01
;10(
9
):1312-1329.
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer.
Wu Q, Ba-Alawi W, Deblois G, Cruickshank J, Duan S, Lima-Fernandes E, Haight J, Tonekaboni SAM, Fortier AM, Kuasne H, McKee TD, Mahmoud H, Kushida M, Cameron S, Dogan-Artun N, Chen W, Nie Y, Zhang LX, Vellanki RN, Zhou S, Prinos P, Wouters BG, Dirks PB, Done SJ, Park M, Cescon DW, Haibe-Kains B, Lupien M, Arrowsmith CH
Nat Commun
2020-08-21
;11(
1
):4205.
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.
Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Deblois G, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, Kanshin E, Sánchez-Osuna M, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Tyers M, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MD
Cell
2020-06-11
;181(
6
):1329-1345.e24.
A chemical toolbox for the study of bromodomains and epigenetic signaling.
Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, Arrowsmith CH, Müller S, Fedorov O, Filippakopoulos P, Knapp S
Nat Commun
2019-04-23
;10(
1
):1915.
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.
Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, Shiah YJ, Barsyte-Lovejoy D, Hofer S, Bader G, Lupien M, Arrowsmith C, Knapp S, De Carvalho D, Berman H, Boutros PC, Kislinger T, Khokha R
J. Cell Biol.
2018-08-06
;217(
8
):2951-2974.
The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.
Boukhaled GM, Cordeiro B, Deblois G, Dimitrov V, Bailey SD, Holowka T, Domi A, Guak H, Chiu HH, Everts B, Pearce EJ, Lupien M, White JH, Krawczyk CM
Cell Rep
2016-08-16
;16(
7
):1829-37.
Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network.
Samuel N, Wilson G, Id Said B, Pan A, Deblois G, Fischer NW, Alexandrova R, Casallo G, Paton T, Lupien M, Gariepy J, Merico D, Hudson TJ, Malkin D
Oncotarget
2016-08-02
;7(
31
):49611-49622.
ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.
Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V
Nat Commun
2016-07-12
;7:12156.
ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction.
Perry MC, Dufour CR, Eichner LJ, Tsang DW, Deblois G, Muller WJ, Giguère V
Mol. Cell. Biol.
2014-12-01
;34(
23
):4232-43.
Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors.
Labbé DP, Nowak DG, Deblois G, Lessard L, Giguère V, Trotman LC, Tremblay ML
Mol. Cancer Res.
2014-02-01
;12(
2
):184-9.
PGC-1α supports glutamine metabolism in breast cancer.
McGuirk S, Gravel SP, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J
Cancer Metab
2013-12-05
;1(
1
):22.
The PGC-1/ERR signaling axis in cancer.
Deblois G, St-Pierre J, Giguère V
Oncogene
2013-07-25
;32(
30
):3483-90.
b-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.
Schade B, Lesurf R, Sanguin-Gendreau V, Bui T, Deblois G, O'Toole SA, Millar EK, Zardawi SJ, Lopez-Knowles E, Sutherland RL, Giguère V, Kahn M, Hallett M, Muller WJ
Cancer Res.
2013-07-15
;73(
14
):4474-87.
Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond.
Deblois G, Giguère V
Nat. Rev. Cancer
2013-01-01
;13(
1
):27-36.
Estrogen-related receptor α, the molecular clock, and transcriptional control of metabolic outputs.
Giguère V, Dufour CR, Eichner LJ, Deblois G, Cermakian N
Cold Spring Harb. Symp. Quant. Biol.
2012-06-15
;76:57-61.
PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.
Lessard L, Labbé DP, Deblois G, Bégin LR, Hardy S, Mes-Masson AM, Saad F, Trotman LC, Giguère V, Tremblay ML
Cancer Res.
2012-03-15
;72(
6
):1529-37.
Cancer: Reprogramming clinical outcome.
Deblois G, Giguère V
Nature
2012-01-18
;481(
7381
):275-6.
Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease.
Deblois G, Giguère V
Biochim. Biophys. Acta
2011-08-01
;1812(
8
):1032-40.
Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis.
Deblois G, Chahrour G, Perry MC, Sylvain-Drolet G, Muller WJ, Giguère V
Cancer Res.
2010-12-15
;70(
24
):10277-87.
An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.
Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguère V
Mol. Endocrinol.
2010-07-01
;24(
7
):1349-58.
Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity.
Deblois G, Hall JA, Perry MC, Laganière J, Ghahremani M, Park M, Hallett M, Giguère V
Cancer Res.
2009-07-31
;69(
15
):6149-57.
Nuclear receptor location analyses in mammalian genomes: from gene regulation to regulatory networks.
Deblois G, Giguère V
Mol. Endocrinol.
2008-09-01
;22(
9
):1999-2011.
Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression.
Blanchette M, Bataille AR, Chen X, Poitras C, Laganière J, Lefèbvre C, Deblois G, Giguère V, Ferretti V, Bergeron D, Coulombe B, Robert F
Genome Res.
2006-05-01
;16(
5
):656-68.
From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response.
Laganière J, Deblois G, Lefebvre C, Bataille AR, Robert F, Giguère V
Proc. Natl. Acad. Sci. U.S.A.
2005-08-16
;102(
33
):11651-6.
Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells.
Laganière J, Deblois G, Giguère V
Mol. Endocrinol.
2005-06-01
;19(
6
):1584-92.
Estrogen-related receptor alpha (ERRalpha) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine.
Carrier JC, Deblois G, Champigny C, Levy E, Giguère V
J. Biol. Chem.
2004-12-10
;279(
50
):52052-8.
Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation.
Deblois G, Giguère V
J. Steroid Biochem. Mol. Biol.
2003-06-01
;85(
2-5
):123-31.
Nuclear receptor target gene discovery using high-throughput chromatin immunoprecipitation.
Laganière J, Deblois G, Giguère V
Methods Enzymol
2003-01-01
;364:339-50.