Principal Investigator

François Major

RNA Engineering

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François Major is one of the precursors of bioinformatics. While beginning his postgraduate studies in computer science at the Université de Montréal in 1984, he applied his knowledge in that field to answer questions relating to biology. His work led him to develop RNA three-dimensional modelling software under the supervision of Robert Cedergren and Guy Lapalme.

After receiving his Ph.D. in 1990, the Investigator completed postdoctoral training at the NCBI under the direction of David Lipman. He was hired by the Université de Montréal in 1994 as an Investigator. In 2005, he was recruited by the IRIC as a Principal Investigator.

Principal Investigator, RNA Engineering Research Unit, IRIC

Professor, Department of Computer Science and Operations Research, Faculty of Arts and Sciences, Université de Montréal

Accredited Member, Department of Biochemistry, Faculty of Medicine, Université de Montréal

Member, Centre Robert-Cedergren, Université de Montréal

Research unit on RNA engineering

Marcelle-Coutu Pavilion, 3306-11

Phone (office)
(514) 343-6752
Fax
(514) 343-7780
Email
francois.major@umontreal.ca
Apply for a M.Sc. or a Ph.D.

RNA Engineering

François Major’s team specializes in RNA Engineering. Its research aims to predict the tertiary structure of RNAs starting from their sequence, to model interaction networks involving microRNAS and to develop targeted therapies based on a RNA capable of blocking the proliferation of cancer cells to cure and even prevent cancer.

Discover the research unit View the research team

Research topics

Publications

  • July 8, 2024

    Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform.

    Quenneville J, Feghaly A, Tual M, Thomas K, Major F, Gagnon E
    Cancer Gene Ther 2024-07-08 ;

  • September 4, 2023

    Automatic recognition of complementary strands: lessons regarding machine learning abilities in RNA folding.

    Chasles S, Major F
    Front Genet 2023-09-04 ;14:1254226

  • August 1, 2023

    D-ORB: A Web Server to Extract Structural Features of Related But Unaligned RNA Sequences.

    Dupont MJ, Major F
    J Mol Biol 2023-08-01 ;435( 15 ):168181

  • April 20, 2023

    The DynaSig-ML Python package: automated learning of biomolecular dynamics-function relationships.

    Mailhot O, Major F, Najmanovich R
    Bioinformatics 2023-04-20 ;

  • See all publications