55 results
CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216.
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard E, Thibault P, Bonneil E, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith M, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm B, Cellot S
Blood Adv
2023-09-20
;.
Defining the elusive oncogenic role of the methyltransferase TMT1B.
Denford SE, Wilhelm B
Front Oncol
2023-01-01
;13:1211540.
Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis.
Milan T, Celton M, Lagacé K, Roques E, Safa-Tahar-Henni S, Bresson E, Bergeron A, Hebert J, Meshinchi S, Cellot S, Barabé F, Wilhelm B
Haematologica
2022-01-01
;107(
1
):86-99.
MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus.
Bulaeva E, Pellacani D, Nakamichi N, Hammond CA, Beer PA, Lorzadeh A, Moksa M, Carles A, Bilenky M, Lefort S, Shu J, Wilhelm B, Weng AP, Hirst M, Eaves CJ
Blood
2020-12-10
;136(
24
):2764-2773.
Cryptic recurrent ACIN1-NUTM1 fusions in non-KMT2A-rearranged infant acute lymphoblastic leukemia.
Pincez T, Landry JR, Roussy M, Jouan L, Bilodeau M, Laramée L, Couture F, Sinnett D, Gendron P, Hébert J, Oligny L, Rouette A, Tran TH, Wilhelm B, Bittencourt H, Cellot S
Genes Chromosomes Cancer
2019-12-03
;59(
2
):125-130.
Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad E, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm B, Cellot S
Blood Adv
2019-11-12
;3(
21
):3307-3321.
Pediatric leukemia: Moving toward more accurate models.
Milan T, Canaj H, Villeneuve C, Ghosh A, Barabé F, Cellot S, Wilhelm B
Exp. Hematol.
2019-06-01
;74:1-12.
NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy.
Roussy M, Bilodeau M, Jouan L, Tibout P, Laramée L, Lemyre E, Léveillé F, Tihy F, Cardin S, Sauvageau C, Couture F, Louis I, Choblet A, Patey N, Gendron P, Duval M, Teira P, Hébert J, Wilhelm B, Choi JK, Gruber TA, Bittencourt H, Cellot S
Genes Chromosomes Cancer
2018-06-01
;57(
6
):311-319.
Identification of novel biomarkers for MLL-translocated acute myeloid leukemia.
Lagacé K, Barabé F, Hébert J, Cellot S, Wilhelm B
Exp. Hematol.
2017-12-01
;56:58-63.
Synthetic human leukemia models: towards precision medicine.
Cellot S, Wilhelm B, Barabé F
Oncotarget
2017-11-14
;8(
57
):96480-96481.
MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets.
Lemieux S, Sargeant T, Laperrière D, Ismail H, Boucher G, Rozendaal M, Lavallée VP, Ashton-Beaucage D, Wilhelm B, Hébert J, Hilton DJ, Mader S, Sauvageau G
Nucleic Acids Res.
2017-07-27
;45(
13
):e122.
Mining Cancer Transcriptomes: Bioinformatic Tools and the Remaining Challenges.
Milan T, Wilhelm B
Mol Diagn Ther
2017-06-01
;21(
3
):249-258.
Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target.
Barabé F, Gil L, Celton M, Bergeron A, Lamontagne V, Roques É, Lagacé K, Forest A, Johnson R, Pécheux L, Simard J, Pelloux J, Bellemare-Pelletier A, Gagnon E, Hébert J, Cellot S, Wilhelm B
Leukemia
2017-05-01
;31(
5
):1166-1176.
Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells.
Gaudreau MC, Grapton D, Helness A, Vadnais C, Fraszczak J, Shooshtarizadeh P, Wilhelm B, Robert F, Heyd F, Möröy T
Sci Rep
2016-06-07
;6:27379.
Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells.
Rentas S, Holzapfel NT, Belew MS, Pratt GA, Voisin V, Wilhelm B, Bader GD, Yeo GW, Hope KJ
Nature
2016-04-28
;532(
7600
):508-11.
Cascade: an RNA-seq visualization tool for cancer genomics.
Shifman AR, Johnson RM, Wilhelm B
BMC Genomics
2016-01-01
;17(
1
):75.
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G
Nat. Genet.
2015-09-01
;47(
9
):1030-7.
Whole genome and transcriptome analysis of a novel AML cell line with a normal karyotype.
Gosse G, Celton M, Lamontagne V, Forest A, Wilhelm B
Leuk. Res.
2015-07-01
;39(
7
):709-18.
Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.
Celton M, Forest A, Gosse G, Lemieux S, Hebert J, Sauvageau G, Wilhelm B
Leukemia
2014-08-01
;28(
8
):1617-26.
An exchange of alternative ATPases within BAF complexes accompanies the transition from hemopoietic stem cell quiescence to proliferation.
Buscarlet M, Krasteva V, Ho L, Simon C, Hebert J, Wilhelm B, Crabtree G, Sauvageau G, Thibault P, Lessard J
Exp. Hematol.
2014-08-01
;42(
8 Suppl
):S4.
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.
Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard J
Blood
2014-03-13
;123(
11
):1720-8.
HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA.
Dormoy-Raclet V, Cammas A, Celona B, Lian XJ, van der Giessen K, Zivojnovic M, Brunelli S, Riuzzi F, Sorci G, Wilhelm B, Marco SD, Donato R, Bianchi ME, Gallouzi IE
Nat Commun
2013-09-04
;4:2388.
Harnessing virtual machines to simplify next-generation DNA sequencing analysis.
Nocq J, Celton M, Gendron P, Lemieux S, Wilhelm B
Bioinformatics
2013-09-01
;29(
17
):2075-83.
RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.
Cellot S, Hope KJ, Chagraoui J, Sauvageau G, Deneault E, Macrae T, Mayotte N, Wilhelm B, Landry JR, Ting SB, Krosl J, Humphries K, Thompson A, Sauvageau G
Blood
2013-08-29
;122(
9
):1545-55.
Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity.
Deneault E, Wilhelm B, Bergeron A, Barabé F, Sauvageau G
Exp. Hematol.
2013-05-01
;41(
5
):470-478.e4.
The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.
Delisle JS, Giroux M, Boucher G, Landry JR, Hardy MP, Lemieux S, Jones RG, Wilhelm B, Perreault C
Genes Immun.
2013-03-01
;14(
2
):115-26.
Impaired natural killer cell self-education and “missing-self” responses in Ly49-deficient mice.
Bélanger S, Tu MM, Rahim MM, Mahmoud AB, Patel R, Tai LH, Troke AD, Wilhelm B, Landry JR, Zhu Q, Tung KS, Raulet DH, Makrigiannis AP
Blood
2012-07-19
;120(
3
):592-602.
Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells.
Gaudreau MC, Heyd F, Bastien R, Wilhelm B, Möröy T
J. Immunol.
2012-06-01
;188(
11
):5377-88.
A role for GPx3 in activity of normal and leukemia stem cells.
Herault O, Hope KJ, Deneault E, Mayotte N, Chagraoui J, Wilhelm B, Cellot S, Sauvageau G, Andrade-Navarro MA, Hébert J, Sauvageau G
J. Exp. Med.
2012-05-07
;209(
5
):895-901.
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.
Simon C, Chagraoui J, Krosl J, Gendron P, Wilhelm B, Lemieux S, Boucher G, Chagnon P, Drouin S, Lambert R, Rondeau C, Bilodeau A, Lavallée S, Sauvageau G, Hébert J, Sauvageau G
Genes Dev.
2012-04-01
;26(
7
):651-6.
C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.
Bisaillon R, Wilhelm B, Krosl J, Sauvageau G
Blood
2011-10-27
;118(
17
):4682-9.
RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.
Wilhelm B, Briau M, Austin P, Faubert A, Boucher G, Chagnon P, Hope K, Girard S, Mayotte N, Landry JR, Hébert J, Sauvageau G
Blood
2011-01-13
;117(
2
):e27-38.
Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast.
Wilhelm B, Marguerat S, Aligianni S, Codlin S, Watt S, Bähler J
Genome Biol.
2011-01-01
;12(
8
):R82.
A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations.
Krosl J, Mamo A, Chagraoui J, Wilhelm B, Girard S, Louis I, Lessard J, Perreault C, Sauvageau G
Blood
2010-09-09
;116(
10
):1678-84.
Defining transcribed regions using RNA-seq.
Wilhelm B, Marguerat S, Goodhead I, Bähler J
Nat Protoc
2010-02-01
;5(
2
):255-66.
The Schizosaccharomyces pombe JmjC-protein, Msc1, prevents H2A.Z localization in centromeric and subtelomeric chromatin domains.
Buchanan L, Durand-Dubief M, Roguev A, Sakalar C, Wilhelm B, Strålfors A, Shevchenko A, Aasland R, Shevchenko A, Ekwall K, Francis Stewart A
PLoS Genet.
2009-11-01
;5(
11
):e1000726.
The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.
Aligianni S, Lackner DH, Klier S, Rustici G, Wilhelm B, Marguerat S, Codlin S, Brazma A, de Bruin RA, Bähler J
PLoS Genet.
2009-08-01
;5(
8
):e1000626.
RNA-Seq-quantitative measurement of expression through massively parallel RNA-sequencing.
Wilhelm B, Landry JR
Methods
2009-07-01
;48(
3
):249-57.
Next-generation sequencing: applications beyond genomes.
Marguerat S, Wilhelm B, Bähler J
Biochem. Soc. Trans.
2008-10-01
;36(
Pt 5
):1091-6.
Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.
Wilhelm B, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J
Nature
2008-06-26
;453(
7199
):1239-43.
Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries.
Gordon M, Holt DG, Panigrahi A, Wilhelm B, Erdjument-Bromage H, Tempst P, Bähler J, Cairns BR
Mol. Cell. Biol.
2007-06-01
;27(
11
):4058-69.
Shaken not stirred: a global research cocktail served in Hinxton.
Marguerat S, Wilhelm B, Bähler J
Genome Biol.
2007-01-01
;8(
11
):320.
The more the merrier: comparative analysis of microarray studies on cell cycle-regulated genes in fission yeast.
Marguerat S, Jensen TS, de Lichtenberg U, Wilhelm B, Jensen LJ, Bähler J
Yeast
2006-03-01
;23(
4
):261-77.
Rapid expansion of the Ly49 gene cluster in rat.
Wilhelm B, Mager DL
Genomics
2004-07-01
;84(
1
):218-21.
Complex controls: the role of alternative promoters in mammalian genomes.
Landry JR, Mager DL, Wilhelm B
Trends Genet.
2003-11-01
;19(
11
):640-8.
Transcriptional control of murine CD94 gene: differential usage of dual promoters by lymphoid cell types.
Wilhelm B, Landry JR, Takei F, Mager DL
J. Immunol.
2003-10-15
;171(
8
):4219-26.
Ly49 genes in non-rodent mammals.
Gagnier L, Wilhelm B, Mager DL
Immunogenetics
2003-05-01
;55(
2
):109-15.
Identification of a new murine lectin-like gene in close proximity to CD94.
Wilhelm B, Mager DL
Immunogenetics
2003-04-01
;55(
1
):53-6.
Acquisition of MHC-specific receptors on murine natural killer cells.
Veinotte LL, Wilhelm B, Mager DL, Takei F
Crit. Rev. Immunol.
2003-01-01
;23(
4
):251-66.
Sequence analysis of the ly49 cluster in C57BL/6 mice: a rapidly evolving multigene family in the immune system.
Wilhelm B, Gagnier L, Mager DL
Genomics
2002-12-01
;80(
6
):646-61.