Research field

Chemical & Structural Biology

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Application of chemical analysis techniques to study and manipulate biological systems. Determination of the structure of biological macromolecules and understanding of how alterations of these structures affect their functions.

Principal Investigators

  • Vincent Archambault

    Cell Cycle Regulation

  • Delphine Bouilly

    Design and Application of Electronic Nanobiosensors

  • Matthew Smith

    Cancer Signalling and Structural Biology

  • Marc Therrien

    Intracellular Signalling

  • Pierre Thibault

    Proteomics and Mass Spectrometry

Publications

  • August 26, 2024

    Nuclear reassembly defects after mitosis trigger apoptotic and p53-dependent safeguard mechanisms in Drosophila.

    Li J, Jordana L, Mehsen H, Wang X, Archambault V
    PLoS Biol 2024-08-26 ;22( 8 ):e3002780

  • August 21, 2024

    A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin.

    Koszela J, Pham NT, Shave S, St-Cyr D, Ceccarelli DF, Orlicky S, Marinier A, Sicheri F, Tyers M, Auer M
    Bioconjug Chem 2024-08-21 ;

  • July 15, 2024

    Complex interplay between RAS GTPases and RASSF effectors regulates subcellular localization of YAP.

    Singh S, Bernal Astrain G, Hincapie AM, Goudreault M, Smith M
    EMBO Rep 2024-07-15 ;

  • See all publications