Hematopoiesis and Leukemia
under the supervision of
TRANG HOANG, Ph.D.
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- Canada Research Chair in Cell Differentiation and the Genetics of Acute Leukemias
- Full Professor, Department of Pharmacology, Faculty of Medicine, Université de Montréal
- Director, Molecular Biology Programs, Faculty of Graduate Studies, Université de Montréal
- Accredited Member, Department of Biochemistry, Faculty of Medicine, Université de Montréal
- Adjunct Member, Department of Experimental Medicine, McGill University
Our research team studies the mechanisms that determine the generation and diversification of blood cells from a very small number of multipotent hematopoietic stem cells. The diversity of potentials of these cells is intrinsically determined by their expressing a complex network of transcription factors. We have observed that an intrinsic disruption of this network by some oncogenes causes differentiation arrest and induces leukemia.
How differentiation emerges and how the cells integrate signals from the environment to keep the hematopoietic system stable are questions of interest. One of the team’s discoveries has revealed that a gene called Stem Cell Leukemia (SCL) plays a critical role in blood cell formation. A disruption of normal regulatory processes causes ectopic SCL expression in the thymus and can result in leukemia.
Current investigation involves cellular studies of transgenic or knock-out mouse models, combined with functional proteomic and genomic approaches, as well as targeted molecular studies.
T + 514 343.6970
F + 514 343.5839
trang.hoang@umontreal.ca |
