Medicinal Chemistry
The role of IRIC's Medicinal Chemistry core facility is to identify, synthesize and develop new chemical entities having biological activity and ultimately a therapeutic efficacy. Its specific objective is to optimize the structure of hit and/or lead compounds, based on in-depth investigation of their Structure-Activity Relationships (SAR).
The Medicinal Chemistry facility is available to scientists who have an interest in developing proprietary and specific molecular tools, or who may want to optimize and further develop small molecules identified as having therapeutic potential. The platform also offers industrial partners an integrated drug discovery team to progress hit or lead compounds through research agreements.
The Medicinal Chemistry team is comprised of medicinal chemists and biologists who have a broad drug discovery experience in an industrial setting. Their established track record, expertise in various therapeutic areas and experience within the large pharma culture, are all significant assets that will be instrumental in adding value to current and future industrial collaborations.
Instruments
State-of-the-art instrumentation is used by the team as they synthesize, purify and analyze new molecules:
- Capillary liquid chromatography coupled with TOF mass spectrometry (LC/MS TOF)
- Analytical and Preparative High pressure liquid chromatography systems (HPLC)
- Automated silica gel flash chromatography purification systems (ISCO)
- Microwave oven with autosampler for chemical reactions
- High field (600 MHz) Varian NMR
In addition, a growing collection of commercial chemical reagents (currently >9000) is available in-house. The chemists and biologists have also access to an online library and literature searching tools.
Pricing
Pricing is established according to the project.
Contacts
For more information about IRIC's Medicinal Chemistry facility, please contact:
Anne Marinier, Ph.D
514 343.6111, ext. 1.17351
anne.marinier@umontreal.ca
