PIERRE THIBAULT, Ph.D.
- Principal Investigator, Proteomics and Bioanalytical Mass Spectrometry Laboratory,
Institute for Research in Immunology and Cancer
- Full Professor, Department of Chemistry, Faculty of Arts and Science, Université de Montréal
- Accredited Member, Department of Biochemistry, Faculty of Medicine, Université de Montréal
- Adjunct Professor, Department of Anatomy and Cell Biology, McGill University
AWARDS & HONOURS
- Canada Research Chair in Proteomics and Bioanalytical Spectrometry, 2004–
- Outstanding Achievement Award, National Research Council of Canada, 1996
- President’s Award, National Research Council of Canada, 1987
TRAINING
- Postdoctoral training with Robert K. Boyd, Institute of Marine Biosciences, National Research Council of Canada, Nova Scotia, 1988-1989
- Ph.D. in analytical chemistry, Université de Montréal, 1988
RESEARCH SUPPORT
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- Canadian Cancer Society Research Institute
- Genome Canada
- Agriculture and Agri-Food Canada
- Agilent Foundation
Pierre Thibault is a principal investigator at the Institute for Research in Immunology and Cancer (IRIC) where he also directs the Proteomics Core Facility. He holds a Canada Research Chair (Tier I) in Proteomics and Bioanalytical Spectrometry.
Dr. Thibault brings his combined expertise in bioanalytical mass spectrometry and protein chemistry to the development and implementation of new technologies in proteomics and cell biology. In multidisciplinary research, these tools provide a deeper understanding of molecular mechanisms and post-translational modifications, which regulate the function and translocation of proteins involved in immunity and signalling in cancer cells.
Before joining IRIC as a founding member in 2004, Dr. Thibault directed the Protein Analysis Department at Caprion Pharmaceuticals (2001-2004). While at Caprion, he developed an important proteomics platform and bioinformatic tools to identify and quantify proteins that are differentially expressed in cancer cells in an immunotherapy program setting.
Pierre Thibault was also Research Officer with the National Research Council of Canada’s Institute of Marine Biosciences in Halifax (1990-1996) and Institute of Biological Sciences in Ottawa (1996-2002) respectively. He won the National Research Council of Canada (NRC) President’s Award for his exceptional contribution to bioanalytical mass spectrometry, as well as the NRC’s Outstanding Merit Award for his innovative work in the development of separation techniques coupled with electrospray ionization methods and their applications in protein chemistry and cell biology.
SELECTED PUBLICATIONS
Trost M, English L, Courcelles L, Desjardins M, Thibault P, (2009) Deciphering the Phagosomal Proteome in Interferon-g Activated Macrophages, Immunity, 30, 143-154
Saba J, Bonneil E, Pomiès C, Eng K, Thibault P, (2009) Enhanced Sensitivity in Proteomics Experiments Using FAIMS Coupled to a Hybrid Linear Ion Trap/Orbitrap Mass Spectrometer, J. Proteome Res., 8, 3355–3366
Gharib M, Marcantonio M, Lehmann SG, Courcelles M, Meloche S, Verrreault A, Thibault P, (2009) Artifactual O-sulfation of silver-stained proteins: Implications for the assignment of phosphorylation and sulfation sites, Mol. Cell. Proteomics, 8, 506-518
Tang Y, Holbert MA, Wurtele H, Meeth K, Rocha W, Gharib M, Jiang E, Thibault P, Verreault A, Cole PA, Marmorstein R, (2008) Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP, Nature Struct. Mol. Biol., 15, 738-745
Marcantonio M, Trost M, Courcelles M, Desjardins M, Thibault P (2008) Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses; application to cell signaling events of interferon-γ stimulated macrophages, Mol. Cell. Proteomics, 7, 645-660.
Fortier MH*, Caron E*, Hardy MP, Voisin G, Lemieux S, Perreault C†, Thibault P†, (2008) The MHC I immunopeptidome is moulded by the transcriptome, J. Exp. Med., 205, 595-610. *Equal contribution, †Equal contribution, corresponding authors.
Drogaris P, Wurtele H, Masumoto H, Verreault A, Thibault P, (2008) Comprehensive profiling of histone modifications using a label-free approach and its applications in determining structure-function relationships, Anal. Chem, 80, 6698-6707
Smith CA, Lau KM, Rahmani Z, Dho SE, Brothers G, Min She Y, Berry DM, Bonneil E, Thibault P, Schweisguth F, Le Borgne R, McGlade CJ (2007) aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb, EMBO J., 26, 468-480.
Ghitun M, Bonneil E, Fortier MH, Yin H, Killeen K, Thibault P (2006) Integrated microfluidic devices with enhanced separation performance: application to phosphoproteome analyses of differentiated cell model systems, J. Sep. Sc., 29, 1539-1549.
Venne K, Bonneil E, Eng K, Thibault P (2005) Improvement in peptide detection for proteomics analyses using NanoLC-MS and high-field asymmetry waveform ion mobility mass spectrometry. Anal Chem 77:2176-2186
Schirm M, Schoenhofen IC, Logan SM, Waldron KC, Thibault P (2005) Identification of unusual bacterial glycosylation by tandem mass spectrometry analyses of intact proteins. Anal Chem 77:7774-7782
Fortier MH, Bonneil E, Goodley P, Thibault P (2005) Integrated microfluidic device for mass spectrometry-based proteomics and its application to biomarker discovery programs. Anal Chem 77:1631-1640
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