SÉBASTIEN LEMIEUX, Ph.D.
AWARDS & HONOURS
- Industrial R&D Fellowships, Natural Sciences and Engineering Research Council of Canada, 2002-2004
- Doctoral Research Award, Canadian Institutes of Health Research, 1999-2002
TRAINING
- Postdoctoral training in bioinformatics with Bo Jiang, Elitra Canada Ltd. (now Merck & Co.), 2002-2004
- Ph.D. in computer science with François Major, Université de Montréal, 2002
- M.Sc. in computer science with François Major, Université de Montréal, 1999
- B.Sc. in microbiology, Université de Montréal, 1997
RESEARCH SUPPORT
- Natural Sciences and Engineering Research Council of Canada
Sébastien Lemieux is a guest investigator at the Institute for Research in Immunology and Cancer (IRIC), where he established the Functional and Structural Bioinformatics Laboratory in fall 2005.
While working on a doctorate in computer science, Dr. Lemieux studied methods of three-dimensional computer RNA modeling. He developed a new graph-theory based representation of the molecular structures of RNA that allows a more complete analysis of known structures, and a much more effective modeling method. He also participated in the development of automated tools to identify and classify molecular interactions within the structure of RNA.
Following this work, Dr. Lemieux did his postdoctoral training at Elitra (now Merck & Co.), where he explored more conventional aspects of bioinformatics, such as sequence analysis, analysis of DNA microarray data, and computer integration of experimental data. During this period, Dr. Lemieux created a system that predicts genes in the fungal pathogen Aspergillus fumigatus. Using this system, scientists at Elitra were the first to identify a large number of essential genes in this important pathogen.
At IRIC, Dr. Lemieux’s focus is on deriving information concealed within data from research conducted by scientists in several disciplines. The goal of one of his projects is to develop a statistical approach that would allow an optimal analysis of DNA microarray data when dealing with a small number of replicates. He is collaborating with his IRIC colleague Dr. François Major on a number of studies Dr. Lemieux puts his expertise in bioinformatics to good use in supporting IRIC scientists in their work.
SELECTED PUBLICATIONS
Lemieux S and Major F (2006) Automated extraction and classification of RNA tertiary structure cyclic motifs. Nucleic Acids Res 34:2340-2346
Lemieux S (2006) Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression. BMC Bioinformatics 7:391
Roemer T, Jiang B, Davison J, Ketela T, Veillette K, Breton A, Tandia F, Linteau A, Sillaots S, Marta C, Martel N, Veronneau S, Lemieux S, Kauffman S, Becker J, Storms R, Boone C, Bussey H (2003) Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol 50:167-181
Lemieux S and Major F (2002) RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire. Nucleic Acids Res 30:4250-4263
Gendron P, Lemieux S, Major F (2001) Quantitative analysis of nucleic acid three-dimensional structures. J Mol Biol 308:919-936
Zhang F, Lemieux S, Wu X, St-Arnaud D, McMurray CT, Major F, Anderson D (1998) Function of hexameric RNA in packaging of bacteriophage phi 29 DNA in vitro. Mol Cell 2:141-147
Lemieux S, Oldziej S, Major F (1998) Nucleic Acids: Qualitative Modeling, in The Encyclopedia of Computational Chemistry, Schleyer, P. v. R. Allinger, N. L., Clark, T. Gasteiger, J., Kollman, P. A., Schaefer III, H. F. Schreiner, P. R. (Eds.); John Wiley & Sons: Chichester
Lemieux S, Chartrand P, Cedergren R, Major F (1998) Modeling active RNA structures using the intersection of conformational space: application to the lead-activated ribozyme. Rna 4:739-749
Major F, Lemieux S, Ftouhi M (1998) Computer RNA Three-Dimensional Modeling from Low-Resolution Data and Multiple-Sequence Information in Molecular Modeling of Nucleic Acids, N.B. Leontis et J. Santa Lucia eds., American Chemical Society Books, Washington, D.C., 394-404
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