LOUIS GABOURY, M.D., Ph.D., F.R.C.P.(C)
- Principal Investigator, Histology Core Facility, Institute for Research in Immunology and Cancer
- Associate Professor, Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal
- Head, Molecular Oncology and Pathology Laboratory, Hôtel-Dieu de Montréal
- Head, Molecular Pathology Research Laboratory,
Centre de recherche du Centre hospitalier de l’Université de Montréal
- President, Quebec Association of Pathologists
AWARDS & HONOURS
- Teaching Excellence Award, Université de Montréal, 1997
- Télésphore Parizeau Award, 1978
TRAINING
- Postdoctoral training with Paul Jolicoeur, Institut de recherches cliniques de Montréal, 1988-1991
- Postdoctoral training with Connie Eaves, Terry Fox Laboratory, BC Cancer Research Centre, 1984-1988
- Ph.D. in experimental pathology, University of British Columbia, 1988
- Post-graduate diploma in anatomic-pathology, Université de Montréal, 1983
- Doctor of Medicine, Université de Montréal, 1978
RESEARCH SUPPORT
Louis Gaboury received his doctoral degree in medicine from the Université de Montréal in 1978. After completing a multidisciplinary medical internship at Hôtel-Dieu de Montréal Hospital, he undertook graduate studies in anatomopathology. Once admitted as anatomical pathologist by the Collège des médecins du Québec, the Royal College of Physicians and Surgeons of Canada and the College of American Pathologists, he pursued further training in experimental pathology at the BC Cancer Centre in Vancouver. He then completed a second postdoctoral fellowship in molecular biology at the Institut de recherches cliniques de Montréal.
Dr. Gaboury started his academic career at the Université de Montréal as Assistant Professor in 1991. At the same time, he joined the department of pathology at Hôtel-Dieu de Montréal Hospital where he established a molecular diagnosis laboratory while continuing to practice medical and surgical pathology. His research at the time sought to analyse point mutations arising in hereditary cancers such as RET mutations in MEN-2 A & MEN-2B syndrome and BRCA-1 & BRCA-2 mutations in familial breast cancers. More recently, he set up the assays for molecular testing for colon cancer arising in the context of defects in Mismatch Repair Genes (MSH-2, MLH-1 and MSH-6).
Dr. Gaboury then became interested in developing molecular tools to assay the overexpression of the HER-2 oncogene. He was able to establish the FISH assay to determine the presence or absence of gene amplification in his laboratory. Because of his expertise, he was appointed member of the National Standards Committee that establishes Canadian guidelines for HER-2 immunhistochemistry assays.
His interest in breast pathology led him to study the human myoepithleial cell lineage during breast development and during breast cancer progression. His research in this area has led to the characterization of the human myoepithlial cell during breast development as well as in the normal and diseased breast tissues.
Since 2003, Dr. Gaboury has been collaborating with Thallion Pharmaceutical (formerly Caprion) in three major projects aimed at the proteomic characterization of three cancers, namely breast, lung, and prostate.
In 2006, Dr. Gaboury was recruited by IRIC to direct its histology core facility. In 2009, he was named Principal Investigator at IRIC where he continues to provide high quality histological services and consultation, and to develop new methods and tools, such as telepathology. Dr. Gaboury divides his time between research, teaching and his clinical work which focuses on medical and surgical pathology.
SELECTED PUBLICATIONS
Bilodeau M, MacRae T, Gaboury L, Laverdure JP, Hardy MP, Mayotte N, Paradis V, Harton S, Perreault C, Sauvageau G. (2009) Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1. PLoS One Oct 19;4(10):e7500.
Hassan S, Ferrario C, Sargovi U, Quenneville L, Gaboury L, Baccarelli A, Salvucco I, Phillips C & Basik M. (2009) The influence of tumor-host interactions in the SDF-1/CXCR4 Ligand/Receptor Axis in Determining Metastatic Risk in Breast Cancer. American Journal of Pathology. 175:66-73.
Voisin L., Julien, C, Duhamel S, Gopalhai K, Claveau I, Saba-El-Leil MK, Rodrigue-Gervais IG, Gaboury L, Lamarre D, Basik M & Meloche S. (2008) Activation of MEK1 or MEK2 isoform is sufficent to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. BMC Cancer. 8:337.
Deslisle JS, Gaboury L, Bélanger MP, Tassé E, Yagita H, Perrault C. (2008) GVHD causes failure of donor hematopoiesis and lymphopoiesis in IFN-γ receptor-deficient hosts. Blood. 112(5), 2111-2119.
Gorska-Flipot I, Sawick J, Gaboury LA, Krajinovic M, Labuda D, Bruckner I, Rouleau D, Ghattas G, Franco EL & Coutlé F for the HIPVIRG study. (2008) Newly-isolated HPV97, related to HPV18 and 45 is frequently detected in HIV-positive men from the Montreal area. Int. J. Cancer. 122, 1195-1197.
Hanna W, O’Malley FP, Barnes P, Berendt R, Gaboury L, Magliocco A, Pettigrew N, Robertson S, Sengupta S, Têtu B, Thomson T. (2007) Updated recommendations from the Canadian National Consensus Meeting on HER-2/neu testing in breast cancer. Curr Oncol. Aug; 14(4):149-153.
Sircar K, Gaboury L, Ouadi L, Mecteau M, Scarlata E, Saad F, Aprikian A, Tanguay S, Lapointe S, Lussier C, Milettei T, Lanoix J. (2006) Isolation of human prostatic epithelial plasma membranes for proteomics using mirror image tissue banking of radical prostatectomy specimens. Clin Cancer Res. 15; 12: 4178-4184.
Krajinovic, M, Richer, C, Gorskà-Flipot, I, Gaboury, L, Novakovic, I, Labuda, Dl, and Sinnett, D. (1998) Genomic loci susceptible to replication errrors in cancer cells. British Journal of Cancer. 78(8):981-5.
Lallier, M, St-Vil, D, Giroux, M, Huot, C, Gaboury, L, Oligny, L, and Desjardins, JG. (1998) Prophylactic Thyroidectomy for Medullary Thyroid Carcinoma in Gene Carriers of MEN 2 Syndrome. Journal of Pediatric Surgery. Vol 33(6):846-848.
Mandeville, R, Franco, E, Ghali, S, Paris-Nadon, L, Rocheleau, N, Mercier, G & Gaboury, L. (1997) Evaluation of the potential carcinogenicity of 60Hz linear sinusoidal continuous wave magnetic fields in Fisher F344 rats. FASEB Journal. 11(3):1127-36.
Villeneuve, L, Pal, PK, Durocher, G, Giasson, R, Blanchard, L & Gaboury, L. (1996) Spectroscopic investigation on the nature of localization of rhodamine 123 and its bromine substituted derivative in different cell lines. J. of Fluorescence. Vol 6(4).
Bérard, J, Gaboury, L, Landers, M, De Repentigny, Y, Kothary, R and Bradley, EC. (1994) Hyperplasia and tumours in lung, breast and other tissues in mice carrying the RAR beta 4-like transgene. Embo J. 13(23):5570-5580.
Dedhar, S, Gaboury, LA, Galloway, P, and Eaves, CJ. (1988) Human GM-CSF is a Growth Factor Active on a Variety of Cell Types of Nonhemopoietic origin. Proc Natl Acad Sci. 85(23):9253-9257.
Eaves, AC, Cashman, JD, Gaboury, LA, Kalousek, DK, and Eaves, CJ. (1986) Unregulated Proliferation of Primitive Chronic Myeloid Leukemia (CML) Progenitors in the Presence of Normal Marrow Adherent Cells. Proc Natl Acad Sci (USA) 83:5306-5310.
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